Objective: Ca2+ overload of muscle fibers is one of the factors that secondarily aggravate the development of Duchenne muscular dystrophy (DMD).The purpose of this study is to evaluate the effects of the Ca2+ channel modulator 2-aminoethoxydiphenyl borate (APB) on skeletal muscle pathology in dystrophin-deficient mdx mice.Methods: Mice were randoml
This study examines the political motives of the plan to expand the new autonomous region in Papua.This is because the expansion of new autonomous areas is not always purely for the welfare of the people but is very closely related to political interests, namely power, and Acrylic Family Puzzle position.This study used qualitative research methods.
Tricho-dento-osseous (TDO) syndrome is a rare, autosomal dominant disorder principally characterised by curly hair at infancy, severe enamel hypomineralization and hypoplasia and taurodontism of teeth, sclerotic bone, and other defects.Diagnostic criteria are based on the generalized enamel defects, severe taurodontism especially of the mandibular
Recent advances in functional neuroimaging techniques, including methodologies such as fNIRS, have enabled the evaluation of inter-brain synchrony (IBS) induced by interpersonal interactions.However, the social interactions assumed in existing dyadic hyperscanning studies do not sufficiently emulate polyadic social interactions in the real world.Th
The growth factor-like lipid mediator, lysophosphatidic acid (LPA), is a potent signaling molecule that influences numerous physiologic and pathologic processes.Manipulation of LPA signaling is of growing pharmacotherapeutic interest, especially because LPA resembles compounds with drug-like features.The action of LPA is mediated through activation